解剖学和形态学
麻醉学
听力与言语-语言病理学
行为科学
心脏和心血管系统
细胞和组织工程学
临床神经病学
危重症监护医学
牙科,口腔外科和医学
皮肤病学
急诊医学
内分泌学和新陈代谢
肠胃学和肝脏学
老人病学和老年医学
卫生保健科学和服务
血液学
免疫学
传染病
综合和补充性医学
医学伦理学
医学信息学
医学实验室技术
医学,全科和内科
医学,法律
医学,研究和试验
神经系统科学
护理
营养学和饮食学
产科医学和妇科医学
肿瘤学
眼科学
整形外科学
耳鼻喉科学
病理学
儿科学
周围血管疾病
药理学和药剂学
生理学
基本医疗保健
精神病学
公共、环境和职业卫生
放射学,核医学和医学成像
康复学
生殖生物学
呼吸系统
风湿病学
运动科学
外科学
毒理学
热带医学
泌尿学和肾脏学
病毒学
老年医学
健康政策和服务
心理学,临床
abstract:BACKGROUND:It is known that essential hypertension may be implicated in the development of cognitive impairment that is associated to microvascular disease of the brain. It has been hypothesized that increased arterial stiffness of the large arteries may lead to microvascular changes due to increased pulsatile flow. Ou...
journal_title:American journal of hypertension
pub_type: 杂志文章
doi:10.1038/ajh.2009.35
更新日期:2009-05-01 00:00:00
abstract:BACKGROUND:Type B acute aortic dissection (AAD) carries a high short- and midterm mortality rate; however, knowledge related to long-term outcome is largely incomplete. The objective of this study was to identify long-term predictors including antihypertensive medications in type B AAD. METHODS:We conducted a clinical...
journal_title:American journal of hypertension
pub_type: 杂志文章
doi:10.1038/ajh.2009.5
更新日期:2009-04-01 00:00:00
abstract:BACKGROUND:Inflammation is an independent risk factor for high blood pressure, and as a consequence inflammatory cytokines could be related with left ventricular hypertrophy (LVH). We sought to assess the association and predictive role of different cytokine levels with LVH in a group of patients with essential hyperte...
journal_title:American journal of hypertension
pub_type: 杂志文章
doi:10.1038/ajh.2008.369
更新日期:2009-04-01 00:00:00
abstract:BACKGROUND:Little is known about the influence of blood pressure (BP) on cardiovascular disease (CVD) outcomes among Asian populations. METHODS:We examined population attributable fractions (PAFs) and hazard ratios (HRs) associated with BP in relation to stroke and coronary heart disease (CHD) incident and mortality w...
journal_title:American journal of hypertension
pub_type: 杂志文章
doi:10.1038/ajh.2008.356
更新日期:2009-03-01 00:00:00
abstract:BACKGROUND:Hypertension is a risk factor for coronary heart disease (CHD), but the causes of hypertension remain largely unknown. Genetic variation is thought to contribute to the etiology of hypertension. We tested a single-nucleotide polymorphism (SNP) (Lys67Arg, rs197922) in the Golgi SNAP Receptor Complex Member 2 ...
journal_title:American journal of hypertension
pub_type: 杂志文章
doi:10.1038/ajh.2008.336
更新日期:2009-02-01 00:00:00
abstract:BACKGROUND:Activation of phosphatidylinositol 3-kinase (PI3K)-Akt signaling by statins increases the activity of endothelial nitric oxide synthase (eNOS). We investigate whether statins (pitavastatin) improve cardiac function and remodeling via eNOS production associated with the PI3K-Akt signaling pathway, Rho-kinase ...
journal_title:American journal of hypertension
pub_type: 杂志文章
doi:10.1038/ajh.2008.333
更新日期:2009-02-01 00:00:00
abstract:BACKGROUND:Components of the renin-angiotensin-aldosterone system (RAAS) and a prothrombotic state are predictors of cardiovascular events in hypertensive patients. A relationship between the RAAS and the coagulation/fibrinolytic systems has been demonstrated, but its clinical relevance in hypertension is unclear. We i...
journal_title:American journal of hypertension
pub_type: 杂志文章
doi:10.1038/ajh.2008.293
更新日期:2008-12-01 00:00:00
abstract:BACKGROUND:Pulse pressure (PP) is an independent predictor of cardiovascular and/or all-cause mortality in patients with underlying cardiovascular disease. We examined whether PP can be used to predict overall mortality in peritoneal dialysis (PD) patients. METHODS:We studied 153 PD patients (mean age, 54.5 +/- 14.2 y...
journal_title:American journal of hypertension
pub_type: 杂志文章
doi:10.1038/ajh.2008.286
更新日期:2008-12-01 00:00:00
abstract:BACKGROUND:This study was conducted to evaluate (i) the effect of nebivolol, a selective beta1-adrenergic receptor antagonist, on plasma concentration of asymmetric dimethylarginine (ADMA) and on flow-mediated dilation (FMD) in essential hypertensive patients; (ii) the effect of serum derived from the treated hypertens...
journal_title:American journal of hypertension
pub_type: 杂志文章,随机对照试验
doi:10.1038/ajh.2008.260
更新日期:2008-11-01 00:00:00
abstract:BACKGROUND:Recent studies have revealed the existence of bone marrow-derived endothelial progenitor cells (EPCs). The number of circulating EPCs might reflect the pathogenesis of atherosclerosis and progression of cardiovascular diseases (CVDs). The purpose of this study was to evaluate the relationship between the num...
journal_title:American journal of hypertension
pub_type: 杂志文章
doi:10.1038/ajh.2008.278
更新日期:2008-11-01 00:00:00
abstract::Several classes of antihypertensive drugs have been shown to improve vascular function through mechanisms other than reducing blood pressure (BP) alone. Certain dihydropyridine calcium channel blockers (CCBs) and inhibitors of the renin-angiotensin system (RAS) increase nitric oxide (NO) bioavailability and decrease o...
journal_title:American journal of hypertension
pub_type: 杂志文章,评审
doi:10.1038/ajh.2008.258
更新日期:2008-10-01 00:00:00
abstract:BACKGROUND:This study was designed to evaluate whether plasma asymmetric dimethylarginine (ADMA) has any role in predicting hemodynamic responses in clinically healthy young subjects. ADMA, as an endogenous nitric oxide (NO) synthase inhibitor, has been demonstrated to associate with hypertension and vascular reactivit...
journal_title:American journal of hypertension
pub_type: 杂志文章
doi:10.1038/ajh.2008.215
更新日期:2008-08-01 00:00:00
abstract:BACKGROUND:Substantial epidemiological evidence documents diverse health benefits, including reduced risks of hypertension, associated with diets high in fiber. Few studies, however, have investigated the extent to which dietary fiber intake in early pregnancy is associated with reductions in preeclampsia risk. We asse...
journal_title:American journal of hypertension
pub_type: 杂志文章
doi:10.1038/ajh.2008.209
更新日期:2008-08-01 00:00:00
abstract:BACKGROUND:The prevalence of hypertension in the Middle East is not well defined. We examined the prevalence, awareness, treatment, and control of hypertension in Iran. METHODS:The Survey of Risk Factors of Noncommunicable Diseases was conducted in 2005 and contains a representative sample of the Iranian adult populat...
journal_title:American journal of hypertension
pub_type: 杂志文章
doi:10.1038/ajh.2008.154
更新日期:2008-06-01 00:00:00
abstract:BACKGROUND:Feeding stroke-prone spontaneously hypertensive rats (SHRSP) a diet rich in fructose results in a profound glucose intolerance not observed in the normotensive Wistar Kyoto (WKY) strain. The aim of this study was to investigate the role of the liver in the underlying mechanisms in the SHRSP. METHODS:SHRSP a...
journal_title:American journal of hypertension
pub_type: 杂志文章
doi:10.1038/ajh.2008.41
更新日期:2008-06-01 00:00:00
abstract:BACKGROUND:There is conflicting information with regard to the effect of beta-blockers on arterial stiffness and wave reflection. We compared a vasodilating beta-blocker, nebivolol, with atenolol. METHODS:We randomized 40 subjects with untreated hypertension (mean +/- s.e.m. systolic/diastolic blood pressure (BP) of 1...
journal_title:American journal of hypertension
pub_type: 杂志文章,随机对照试验
doi:10.1038/ajh.2008.156
更新日期:2008-06-01 00:00:00
abstract:BACKGROUND:As hypertension, obesity, and leanness are reported to be associated with poor cognitive function, it is possible that obesity or leanness in hypertensive patients may also be associated strongly with poor cognitive function. METHODS:We recruited 184 elderly hypertensive patients comprising 93 very elderly ...
journal_title:American journal of hypertension
pub_type: 杂志文章
doi:10.1038/ajh.2008.157
更新日期:2008-06-01 00:00:00
abstract:BACKGROUND:Complement factor H (CFH) is a plasma protein that is essential in the regulation of the alternative complement pathway and has been implicated as taking part in complement inhibition in atherogenesis. We evaluated the association of the Y402H polymorphism with incident coronary heart disease (CHD), incident...
journal_title:American journal of hypertension
pub_type: 杂志文章,多中心研究
doi:10.1038/ajh.2007.81
更新日期:2008-05-01 00:00:00
abstract::The prevalence of left ventricular hypertrophy (LVH) rises with severity of hypertension (HT), age, and obesity. Its prevalence ranges from 20% in mildly hypertensive patients to almost 100% in those with severe or complicated HT. However, the diagnosis of LVH is not straightforward, and the definitions and criteria u...
journal_title:American journal of hypertension
pub_type: 杂志文章,评审
doi:10.1038/ajh.2008.16
更新日期:2008-05-01 00:00:00
abstract:BACKGROUND:Recently, some investigators have shown that telmisartan, an angiotensin II (Ang II)-receptor blocker (ARB), is a partial agonist of the peroxisome proliferator-activated receptor-gamma (PPAR-gamma). We investigate whether telmisartan improves cardiovascular remodeling associated with the production of endot...
journal_title:American journal of hypertension
pub_type: 杂志文章
doi:10.1038/ajh.2008.27
更新日期:2008-05-01 00:00:00
abstract:BACKGROUND:Microalbuminuria is recognized as a marker of generalized vascular dysfunction. However, the associations between microalbuminuria and pulse wave velocity (PWV), carotid intima-media thickness (IMT), and ambulatory blood pressure (ABP), respectively, have not been investigated. METHODS:Brachial-ankle PWV (b...
journal_title:American journal of hypertension
pub_type: 杂志文章
doi:10.1038/ajh.2007.77
更新日期:2008-04-01 00:00:00
abstract::Kidney stones affect hypertensive patients disproportionately compared to normotensive individuals. On the other hand, some prospective data suggest that a history of nephrolithiasis was associated with a greater tendency to develop hypertension. Newer epidemiologic data also link obesity and diabetes, features of the...
journal_title:American journal of hypertension
pub_type: 杂志文章,评审
doi:10.1038/ajh.2007.62
更新日期:2008-03-01 00:00:00
abstract:BACKGROUND:Whether microvascular disease contributes to the development of left ventricular hypertrophy (LVH) is unclear. We examined the relationship of retinal microvascular signs with LVH in an African-American population. METHODS:A population-based, cross-sectional study of 1,439 middle-aged African-American parti...
journal_title:American journal of hypertension
pub_type: 杂志文章
doi:10.1038/ajh.2007.57
更新日期:2008-03-01 00:00:00
abstract:BACKGROUND:Peroxisome proliferator-activated receptor-gamma (PPAR-gamma) is a member of the nuclear receptor family that has been implicated in cell differentiation and proliferation, glucose metabolism, macrophage development, and inflammatory responses. PPAR-gamma can be activated by a range of synthetic substances a...
journal_title:American journal of hypertension
pub_type: 杂志文章
doi:10.1038/ajh.2007.39
更新日期:2008-02-01 00:00:00
abstract:BACKGROUND:Pulse pressure, a measure of central arterial stiffness and a predictor of cardiovascular mortality, has known genetic components. METHODS:To localize the genetic effects of pulse pressure, we conducted a genome-wide linkage analysis of 1,892 American-Indian participants of the Strong Heart Family Study (SH...
journal_title:American journal of hypertension
pub_type: 杂志文章
doi:10.1038/ajh.2007.34
更新日期:2008-02-01 00:00:00
abstract:BACKGROUND:The renin-angiotensin system (RAS) plays a major role in promoting left ventricular (LV) remodeling in essential hypertension. We designed a controlled, randomized pilot study aimed to test the hypothesis that the dual RAS blockade with angiotensin-converting enzyme (ACE) inhibitor (ACEi) + angiotensin II re...
journal_title:American journal of hypertension
pub_type: 杂志文章,随机对照试验
doi:10.1038/ajh.2007.47
更新日期:2008-02-01 00:00:00
abstract:BACKGROUND:Coffee is a rich source of antioxidative polyphenols, but epidemiological studies and interventional trials have failed to demonstrate any clear beneficial effects of coffee consumption on hypertension. The interaction between hydroxyhydroquinone (HHQ) and 5-caffeoylquinic acid (CQA) was examined, in an atte...
journal_title:American journal of hypertension
pub_type: 杂志文章
doi:10.1038/ajh.2007.3
更新日期:2008-01-01 00:00:00
abstract:BACKGROUND:Most healthy people exhibit a decrease in systolic blood pressure (SBP) at night. A drop of <10% from mean daytime values, "non-dipping," is associated with kidney disease and cardiovascular events. We hypothesized that non-dipping would predict all-cause mortality. METHODS:Consecutive patients referred for...
journal_title:American journal of hypertension
pub_type: 杂志文章
doi:10.1038/ajh.2007.7
更新日期:2008-01-01 00:00:00
abstract:BACKGROUND:Preeclampsia is a human pregnancy-associated syndrome associated with hypertension, proteinuria, and endothelial dysfunction. We tested whether increased reactive oxygen species (superoxide and peroxynitrite) production and decreased bioavailability of the endothelial nitric oxide (NO) synthase (eNOS) cofact...
journal_title:American journal of hypertension
pub_type: 杂志文章
doi:10.1016/j.amjhyper.2007.08.007
更新日期:2007-12-01 00:00:00
abstract:BACKGROUND:We previously showed that the infusion of tumor necrosis factor alpha (TNF-alpha) induces hypertension and vascular dysfunction in late pregnant but not virgin rats. In the present study, we tested the hypothesis that levels of ovarian hormones to mimic pregnancy are required for TNF-alpha-induced changes in...
journal_title:American journal of hypertension
pub_type: 杂志文章
doi:10.1016/j.amjhyper.2007.07.002
更新日期:2007-11-01 00:00:00
abstract:BACKGROUND:The adverse association between blood pressure and carotid artery intima-media thickness (IMT), a surrogate measure of subclinical atherosclerosis, is well-known. However, whether the G-6A polymorphism of the angiotensinogen (AGT) gene, a candidate gene of hypertension and vascular remodeling, modulates this...
journal_title:American journal of hypertension
pub_type: 杂志文章
doi:10.1016/j.amjhyper.2007.06.001
更新日期:2007-10-01 00:00:00
abstract:BACKGROUND:The W allele of the G460W polymorphism in the adducin-1 gene has been occasionally associated with increased blood pressure (BP). The aim of this study was to test whether the G460W variant is associated with BP levels and BP progression rate and whether G460W associations with BP are affected by sex, body m...
journal_title:American journal of hypertension
pub_type: 杂志文章
doi:10.1016/j.amjhyper.2007.04.007
更新日期:2007-09-01 00:00:00
abstract:BACKGROUND:African-American men have stiffer arteries than white men at rest. We sought to test the hypothesis that reductions in stiffness after aerobic exercise may be attenuated in African-American (AA) men compared with white (W) men. METHODS:Twenty-four young men (age 22+/-1.0 years; 12 AA and 12 W) underwent mea...
journal_title:American journal of hypertension
pub_type: 杂志文章
doi:10.1016/j.amjhyper.2007.03.015
更新日期:2007-08-01 00:00:00
abstract:BACKGROUND:We have recently shown that the renin enhancer, a regulatory element of renin gene transcription, is important in the long-term control of basal blood pressure (BP). In this study, we examined whether the renin enhancer deficit alters the acute pressor response to emotional stress in mice. METHODS:Under flu...
journal_title:American journal of hypertension
pub_type: 杂志文章
doi:10.1016/j.amjhyper.2007.02.010
更新日期:2007-08-01 00:00:00
abstract:BACKGROUND:Reduced synthesis of nitric oxide (NO) is considered a major proatherogenic mechanism in patients with end-stage renal disease (ESRD), but genetic factors impinging on this mechanism have been little studied in this population. METHODS:We tested the relationship between carotid intima-media thickness (IMT) ...
journal_title:American journal of hypertension
pub_type: 杂志文章
doi:10.1016/j.amjhyper.2007.02.009
更新日期:2007-07-01 00:00:00
abstract:BACKGROUND:Although the acute increase of arterial stiffness and blood pressure (BP) after cigarette smoking in healthy smokers is considered a possible mechanism of increased cardiovascular risk, the acute effect of smoking on arterial stiffness in hypertensive smokers is unknown. We investigated the acute effects of ...
journal_title:American journal of hypertension
pub_type: 杂志文章
doi:10.1016/j.amjhyper.2006.12.017
更新日期:2007-06-01 00:00:00
abstract:BACKGROUND:This study evaluated the effect of chronic sucrose feeding on hemodynamic parameters and renal sympathetic nervous activity. In addition, angiotensin I, II, and 1-7 levels were determined in plasma, heart, kidney, and the epididymal adipose tissue. METHODS:Male Wistar rats were treated for 30 days with 20% ...
journal_title:American journal of hypertension
pub_type: 杂志文章
doi:10.1016/j.amjhyper.2007.01.014
更新日期:2007-06-01 00:00:00
abstract:BACKGROUND:Retinal abnormalities, particularly arteriolar narrowing, are powerful predictors of cardiovascular events. The precision of internists and ophthalmologists in the assessment of retinal vessels widths has been disputed but not evaluated against a technology of edge detection. METHODS:Fifty-two patients with...
journal_title:American journal of hypertension
pub_type: 杂志文章
doi:10.1016/j.amjhyper.2006.10.012
更新日期:2007-05-01 00:00:00
abstract:BACKGROUND:Left ventricular (LV) concentric geometry and hypertrophy, depressed wall mechanics, and abnormal diastolic properties have been described in the diabetic heart. However, the cardiac response to dynamic exercise in diabetic patients remains controversial. The present study assessed strain rate (SR) imaging d...
journal_title:American journal of hypertension
pub_type: 杂志文章
doi:10.1016/j.amjhyper.2006.12.009
更新日期:2007-05-01 00:00:00
abstract:BACKGROUND:Hypertension varies in prevalence among race/ethnic groups in the United States. Within-ethnic group differences associated with acculturation have been less frequently examined. We studied the association of three measures of acculturation (language spoken at home, place of birth, and years living in the US...
journal_title:American journal of hypertension
pub_type: 杂志文章
doi:10.1016/j.amjhyper.2006.09.025
更新日期:2007-04-01 00:00:00